Wednesday, December 15, 2010

Unanswerable

"Mo, no one knows what to do in your case anymore, because no one knows what the problem is.
There are no more tests that I can think of to run to answer your questions.
And no one who will be able to tell you what to do, what direction to take. I'm so sorry."

--my local RE, in response to my question of where to go from here
(medical options include another FET, FET with gestational carrier, sperm donor, or egg donor)

Mo

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Tuesday, December 14, 2010

Speak of the devil...and genetics news back

Speak of the devil, my period came - almost immediately after the last post went up. Day one, here we are.

Also, genetics on miscarriage #6 are back.

Normal male.

I don't even know what to think.

Mo

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Do you think it's possible?

Do you think it's possible that my RE turned the vacuum aspirator up too high during my D&C and accidentally sucked out my uterus?

D&C was November 11th. It is now December 14th...and no period in sight.

I don't mean to be vulgar, but I'm starting to wonder a little bit...

Mo

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Tuesday, December 7, 2010

Placental pathology results


(pic brought to you by whywouldyouknitthat.blogspot.com)


Not sure if I mentioned it, but after our most recent miscarriage, my RE here in NYC recommended we send slides from the chorionic villi to a placental pathologist at Yale for review (the same guy who performed my endometrial function test).

So we did.

Once I looked into it, I found out that this placental pathology analysis would be covered by insurance, and so I decided to send slides from not only this miscarriage but also from the other four we've had tested.

Results just came back. All of the reports are similar in saying that there were various findings that provided evidence of chromosomal abnormality (including this latest one with the CCS normal blastocyst, which demonstrated trophoblast hyperplasia - it will be so interesting to see what the genetics come back as). All of the losses also demonstrated that maternal uteroplacental blood flow was normal.

All of the miscarriage reports also report what was NOT found:
  • no evidence of immunologic rejection
  • no evidence of bacterial ascending infection
  • no evidence of thrombotic pathology
Not sure if I want this latest loss to be a chromosomal abnormality that somehow slipped through the cracks or rather have it unexplained. Pretty much would rather not be in this situation at all! I guess the best I can come up with is that it will be good to get the information back and then try to make sense of it.

On the placental pathology report from the latest loss, there was one section that has me a bit confused.

Any medical types are most welcome to weigh in...

On this last report only, the pathologist said "this patient and/or her spouse may also have an occult genetic abnormality. A genetic consultation, including high resolution karyotyping and array analysis of the parents, may therefore be beneficial."

Now what in the world is an occult genetic abnormality? I'm assuming here that word occult means "hidden," rather than "supernatural." Aren't one's genetics always hidden?

Is this different from a "regular" genetic abnormality?

And what is high resolution karyotyping and array analysis? is this different somehow from the type of karyotyping we've had done already? We both came up as genetically normal...

Anybody have any thoughts or knowledge?

Feel like I'm starting to emerge from my cave of sorrows, pick myself up again, and try to figure out next directions. Geesh, this loss and all else going on have been hard.

Mo


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