IVF # 1 (NYC): September '07, age 35
Long Lupron Protocol
300 Follistim, 5 units Lupron
22 eggs retrieved, 20 mature, 14 fertilized
2 blasts transferred on day 5 (3BB, 1BB), nothing to freeze
BFP!
Betas double appropriately
Fetus measures on track
HB: 140, 151
Missed miscarriage at 8 wks, 4 days.
Cytogenetics: female with trisomy 21 and monosomy x
IVF #2 (NYC): February '08, age 36
Long Lupron Protocol
225 Follistim, 5 units Lupron
11 eggs retrieved, 10 mature, 9 fertilize with ICSI
For personal reasons freeze 6 at 2pn, culture 3, transfer one at day 3.
BFN
(When 6 are thawed three years later, none survive in culture)
Natural Pregnancy: March '08, age 36
Betas double appropriately (223, then 425, then 831)
Missed miscarriage discovered at 7 weeks.
Cytogenetics: Lab loses sample
Natural Pregnancy: May '08, age 36
Beta fails to rise appropriately
Natural miscarriage
Cytogenetics: male with trisomy 16
IVF #3 (NYC): November '08, age 36
Long Lupron Protocol
225 Follistim, 5 units Lupron
12 eggs retrieved, 10 mature, 8 fertilize without ICSI
three embryos transferred at day 3 (8, 7, 6 cells, moderate fragmentation)
BFN
IVF #4 (NYC): February '09, age 37
Antagonist Protocol with endometrial co-culture
Day 2 FSH = 6.8, E2 = 32.7, LH = 5.47
200 Follistim, 75 Menopur
15 eggs retrieved, 14 mature, 11 fertilize without ICSI
five embryos transferred at day 3 after co-culturing (9, 9, 8, 8, 8 cells, minimal fragmentation)
BFN
IVF #5 (NYC): May '09, age 37
Antagonist Protocol with endometrial co-culture
Day 2 FSH = 7.0, E2 = 30, LH = 7.5
200 Follistim, 75 Menopur
Trigger one day early (Day 9)
6 eggs retrieved, 4 mature, 3 fertilized without ICSI
Three embryos transferred at day 3 after co-culturing (9, 8, 7 cells, grade 1 and grade 2)
BFP
HCG levels: 9dp3dt: 23; 11 dp3dt: 48; 13 dp3dt: 36; 15dp3dt: 17
Chemical pregnancy
Natural Pregnancy: June '09, age 37
Beta #1 (15 dpo): 188!, estrogen 271, progesterone 39
Beta #2 (17 dpo): 585!, estrogen 301, progesterone 36.45
Beta #3 (19 dpo): 2,413
Beta #4 (21 dpo): 3,159
Beta #5 (23 dpo): 5,221
5 wk u/s: gestational sac, yolk sac
7 wk u/s: baby w/ heart rate of 167 bpm! Measuring 7 wks 4 days.
8 wk u/s: baby w/ heart rate of 185 bpm! Measuring 8 wks 1 day.
9 wk u/s: no heartbeat (8/6/09). D&C performed.
69XXX - triploidy
IVF #6 (Denver): March '10, age 38
Microdose Lupron Protocol
Day 3 FSH = 5.5, E2 = 33.2, AMH = 1.4
300 gonal-f, 150 menopur, 20 ml lupron every 12 hours
.33 Saizen, .5 dexamethasone
19 eggs retrieved, 14 mature, 16 fertilize with ICSI (13 immediately, 3 more after in vitro maturation with Day 2 ICSI)
7 blastocysts [6BB (Day 7 blast), 4AB (Day 7 blast), 2 x 4BB, 4AA (from Day 2 ICSI), 3BB, 3AB]
Freeze all
Sample sent for sex chromosome FISH testing and microarray to test all chromosomes
Results indicate three normal blastocysts!!!
IVF #7 (Denver): June '10, age 38
(For two months ahead took inositol, coenzyme q10, and melatonin to improve egg quality)
(For two months ahead took inositol, coenzyme q10, and melatonin to improve egg quality)
Microdose Lupron Protocol
300 gonal-f, 150 menopur, 20 ml lupron every 12 hours
.33 Saizen, .5 dexamethasone
25 eggs retrieved, 22 mature, 18 fertilize with ICSI
300 gonal-f, 150 menopur, 20 ml lupron every 12 hours
.33 Saizen, .5 dexamethasone
25 eggs retrieved, 22 mature, 18 fertilize with ICSI
Freeze all
Sample sent for sex chromosome FISH testing and microarray to test all chromosomes
Sample sent for sex chromosome FISH testing and microarray to test all chromosomes
Results indicate five normal blastocysts!!!
FET #1 (Denver): October '10, age 38
Medicated cycle
Took Depot Lupron for two months prior to cycle to improve endometrium
Transferred 3 FISH and microarray confirmed chromosomally normal embryosEmbryo #5 from June - a 6BA, Embryo #14 from June - a 4BB, and Embryo #6 from March - a 6BB
BFP
Start taking 40 mg lovenox, 10 mg prednisone, 40 mg pepcid, 10 mg claritin, baby aspirin, and intralipids for potential immune issues
Beta #1 (9dp5dt) = 26.8, estrogen 526, progesterone 4.87
Beta #2 (11dp5dt) = 56.0, progesterone = 28
Beta #3 (13dp5dt) = 145.5, progesterone = 33
Beta #4 (17dp5dt) = 690, progesterone = 22
Beta #5 (20dp5dt) = 1702, progesterone = 11, estrogen 543
5w5d u/s: gestational sac and yolk sac
6w2d u/s: larger sac + fetal pole?
Beta #6 (31dp5dt) = 12,691, P4 = 23.12
7w3d u/s: no heartbeat, debris in gestational sac. D&C performed.
Cytogenetics: 46XY. Chromosomally normal male baby
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