"An inversion on chromosome 9 is generally thought to be a common and benign polymorphism, but we do not allow donors to donate if they have any type of chromosomal variant, as it could disrupt meiosis and lead to aneuploidy."Basically one piece of our donor's chromsome 9 is reversed end to end.
It looks something like this:
- a higher risk of spontaneous abortion in approximately 30% of those affected (and we need that like we need a hole in the head, frankly)
- potential abnormal ultrasonic findings on fetuses with this abnormality, including hydramnios, anhydramnios, hydroureter, hydronephrosis, encephalocele, and prune belly syndrome.
- that it is a potential cause of psychiatric disorders
- reports of links to congenital genital malformation, mild growth retardation, malformations of the skull and facial (craniofacial) region, undescended testis, skeletal malformations, mental retardation, hermaphroditism, and/or cardiac defects
We feel bad for the donor, too. Because this can't be easy news to hear, even though everything will likely be fine for her (stress on "common" and "benign" variant). No matter what, not what she was expecting when she signed up to donate.
Better to know now than later, but still, what a sucker punch. We are out approximately $10,000. And we are out our dreams and hopes of what a baby with this donor would be like, and have also lost our hopes of moving forward in any timely manner. It took so much emotional work to feel OK about this, about her. And now, well...
I feel like giving up.
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