Thursday, July 1, 2010

FISH results are back: IVF #7


We received a call with the FISH results yesterday, which is the extra test we're having done just to look at the sex chromosomes in each of our blasts. We added this step at the advice of CCRM's genetic counselor who expressed concern that given our history of polyploidy and my history of cancer treatment, we might be more prone to a repeat polyploidy than the general population (usually there's a 1 in 1,000 chance). Since microarray doesn't show polyploidies, just trisomies and monosomies, we forked out some more cash to add this test to the mix.

Last time, this one pesky chromosome knocked out half of our sample. It was really disheartening, although things ended up ok and we got three normals.

And this time?

Well, so far we've got four with normal sex chromosomes!! And the other three? They only had one cell to test for each of the other three and they got no result. So We've got four with normal XY or XX and three wild cards, which will have their fates revealed with microarray. But we haven't lost a single blast yet! Unbelievable.

I felt my breath hitch in my throat when the genetic counselor Danielle identified herself on the phone. I had heard that the policy has changed since our first CCRM cycle and they are now typically sharing FISH and microarray news together once the microarray news comes in. So hearing her voice, I was worried that she was calling this soon because our embryos were ALL ABNORMAL and we could just begin grieving early.

I shared that fear with her and she said, "You know, this may be hard to believe, but maybe this time there won't be a lot of grief. Given your history, that is probably hard to imagine, but I'm really optimistic."

Huh. Not a lot of grief? Really optimistic? About us? Weird.

Here's the detailed rundown of our FISH results:

Embryo #05: 6BA NORMAL!!
Emrbyo #11: 4BB NORMAL!!
Embryo #14: 4BB NORMAL!!
Embryo #15: 3BB NORMAL!!
Embryo #17: 3BB No diagnosis
Embryo #20: 3BC No diagnosis
Embryo #21: 3AB No diagnosis

Three cheers for good news!!!

Only 22 more pairs of chromosomes to go!

The microarray result wait time of late has been 4.5 to 5 weeks...so...we should hear the final word on those results around the end of July. Right now that seems just fine. I can wait.

I pray the news is good.

Mo

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35 comments:

  1. Woohoo! I want some Saizen for my next round!!!!!

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  2. Don't forget we also did the Colorado Cocktail a few months in advance... maybe that helped?

    Although we're not out of the woods yet. I don't want to jinx it!!

    Mo

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  3. WOOHOOOOO!!!! Fantastic news!!!! Can't wait to hear more!

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  4. WOOT! Great super fantastic news!! I hope the MA results come faster than the quoted time, I can't wait that long!!! :)

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  5. Good news! Very happy for you. Praying the microarray brings you similarly fabulous news!

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  6. That is great news! I'm so happy for you. Come on, Little Embies, keep bringing in the good news.

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  7. Hooray for the good news- may it keep coming!

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  8. Glad to read this happy update. Hoping the trend continues!

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  9. Oh I've got goosebumps!!!! Wonderful news Mo, wonderful news!!!

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  10. Sounds good! (and be kind to yourself on lupron, I know how hard it can be for the person taking it and those around them)

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  11. Such great news, let's keep the great news coming!!

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  12. I'm pretty sure that if one of these bebes snuggles in to stay, you're going to need a chromosome onesie from etsy. ♥

    Hurry up, CGH! Who do they use for the testing, Mo? Is it Signature Genomics? Just curious.

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  13. REALLY hoping for some good news for you but the first report sounds AWESOME!!

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  14. Congrats!!! Let's keep the good news coming!!!

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  15. K - a chromsome onesie from etsy?! Do tell! I need details on this!

    I can't remember off the top of my head who they use... the lab is based out of New Jersey if that helps at all...I'm thinking it's Reprogenetics??? Anybody out there know for sure?

    Mo

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  16. Such great news! Still hoping and praying that the good news just keeps on coming!

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  17. I think that CGH is through Reprogenetics.

    Lots of chromosome onesies on cafepress: http://www.cafepress.com/+chromosome+baby-bodysuits

    With FISH do you know the gender of each blast now?

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  18. CCRM knows, but they won't tell me. They did let slip that out of both cycles, the gender mix is about even. Good enough for me : )

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  19. ALRIGHT!!!!! Oh, Mo! So glad for you. Such good news! One hurdle down. YAY!

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  20. So glad the news is good so far. Here's hoping they're all normals!

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  21. Congratulations, Mo! The news keeps getting better and better!

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  22. Awesome, awesome, awesome news! A thousand congratulations!!!

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  23. WHOOOOOOOOOOOHOOOOOOOOOOOOOOOO!!!!!!!!!!!!!!

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  24. fantastic news, the really good news in this is that 3 of your best 4 are confirmed good, so assuming at least a few of those get through microarray then you could be in just a mightly fine position all round. Oh so gut wrenching but truly unbelievable so far.

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  25. Great News!!! You are very patient...going through all these additional steps...but in the end will be worth it when you have a perfect FET in the upcoming months:)

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  26. I got goose bumps reading your post - I just know that one of those beautiful blasts is going to be a sweet little baby in your arms in the near future.

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  27. HOT DAMN!

    goosebumpy here in NH
    best news possible.

    No jinxing, just HOPING in big capital letters.
    XOXO
    Kate

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  28. Mo - I haven't been around in forever. What wonderful results on your frosties. Looks like you have at least 4 perfect little ones on the horizon. Woot Woot!

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